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A 55-year-old woman presented with a non-healing, painless pigmented macule with a superficial ulceration on the left planta, which she said had been there for 6 months. On physical examination, an irregular pigmented macule with a superficial ulceration and brown haemorrhagic crusts was observed on the left

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Efficacy and tolerability of erenumab in patients with episodic migraine in whom two-to-four previous preventive treatments were unsuccessful: a randomised, double-blind, placebo-controlled, phase 3b study
The Lancet
Published: October 22, 2018

ARTICLES

Efficacy and tolerability of erenumab in patients with episodic migraine in whom two-to-four previous preventive treatments were unsuccessful: a randomised, double-blind, placebo-controlled, phase 3b study
The Lancet
Published: October 22, 2018

ARTICLES

Efficacy and tolerability of erenumab in patients with episodic migraine in whom two-to-four previous preventive treatments were unsuccessful: a randomised, double-blind, placebo-controlled, phase 3b study
The Lancet
Published: October 22, 2018

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Acral lentiginous melanoma

A 55-year-old woman presented with a non-healing, painless pigmented macule with a superficial ulceration on the left planta, which she said had been there for 6 months. On physical examination, an irregular pigmented macule with a superficial ulceration and brown haemorrhagic crusts was observed on the left plantar near the heel. A skin biopsy showed a malignant melanoma and immunohistochemical examination of biopsied tissue sections showed positive staining for melanoma associated antigens using the antibodies HMB-45, Melan-A, and S100.

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